Dr Tom Scerri
Research
Investigating the genetic aetiology of developmental dyslexia by genotyping dyslexic individuals and their families for genetic polymorphisms, and then conducting linkage and association analyses. Main focus of interest is on chromosome 18, where linkage for developmental dyslexia has been identified on several occasions. Current efforts involve locating the genetic element(s) on chromosome 18 that are influencing susceptibility to developmental dyslexia. Additionally, an ongoing collaboration with European partners has enabled a whole-genome association study using thousands of dyslexic individuals.
Publications
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DCDC2, KIAA0319 and CMIP Are Associated with Reading-Related Traits. (2011) Scerri TS, Morris AP, Buckingham LL, Newbury DF, Miller LL, Monaco AP, Bishop DV, Paracchini S. Biol Psychiatry. Mar 30. PMID: 21457949 [Epub ahead of print]
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PCSK6 is associated with handedness in individuals with dyslexia. (2010) Scerri TS, Brandler WM, Paracchini S, Morris AP, Ring SM, Talcott JB, Stein J, Monaco AP. Hum Mol Genet. Nov 9. PMID: 21051773 [Epub ahead of print]
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Identification of candidate genes for dyslexia susceptibility on chromosome 18. Scerri TS, Paracchini S, Morris A, MacPhie IL, Talcott J, Stein J, Smith SD, Pennington BF, Olson RK, DeFries JC, Monaco AP. PLoS One. 2010 Oct 28;5(10):e13712. PMID: 21060895
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Genetics of Developmental Dyslexia.Scerri TS, Schulte-Körne, G. European Child and Adolescent Psychiatry. 2009 November online
- Association of the KIAA0319 dyslexia susceptibility gene with reading skills in the general population. Paracchini S, Steer CD, Buckingham LL, Morris AP, Ring S, Scerri T, Stein J, Pembrey ME, Ragoussis J, Golding J, Monaco AP. Am J Psychiatry. 2008 Dec;165(12):1576-84. Epub 2008 Oct 1. PMID: 18829873
- The genetic lexicon of dyslexia. Paracchini S, Scerri T, Monaco AP. Annu Rev Genomics Hum Genet. 2007;8:57-79. Review. PMID: 17444811
- Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Harold D, Paracchini S, Scerri T, Dennis M, Cope N, Hill G, Moskvina V, Walter J, Richardson AJ, Owen MJ, Stein JF, Green ED, O'Donovan MC, Williams J, Monaco AP. Mol Psychiatry. 2006 Dec;11(12):1085-91, 1061. Epub 2006 Oct 10. PMID: 17033633
- The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Paracchini S, Thomas A, Castro S, Lai C, Paramasivam M, Wang Y, Keating BJ, Taylor JM, Hacking DF, Scerri T, Francks C, Richardson AJ, Wade-Martins R, Stein JF, Knight JC, Copp AJ, Loturco J, Monaco AP. Hum Mol Genet. 2006 May 15;15(10):1659-66. Epub 2006 Apr 6. PMID: 16600991
- Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK. Scerri TS, Fisher SE, Francks C, MacPhie IL, Paracchini S, Richardson AJ, Stein JF, Monaco AP. J Med Genet. 2004 Nov;41(11):853-7. PMID: 15520411
- A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Francks C, Paracchini S, Smith SD, Richardson AJ, Scerri TS, Cardon LR, Marlow AJ, MacPhie IL, Walter J, Pennington BF, Fisher SE, Olson RK, DeFries JC, Stein JF, Monaco AP. Am J Hum Genet. 2004 Dec;75(6):1046-58. Epub 2004 Oct 22. PMID: 15514892