Dr Stephen Chapman

Clinical Lecturer in Respiratory Medicine

Research summary

I graduated from the University of Oxford Medical School in 1998, and have subsequently pursued a career in Respiratory and General (Internal) Medicine. I have recently taken up the post of Clinical Lecturer in Respiratory Medicine at the University of Oxford, following an initial period of research studying human genetic susceptibility to invasive bacterial infection. During this period I identified an association between the major autoimmune susceptibility locus PTPN22 and susceptibility to invasive pneumococcal disease and thoracic empyema (Chapman SJ et al., Nature Genetics 2006; 38(5): 499-500). This was both the first genetic polymorphism to be identified in association with empyema, and the first infectious disease to be associated with PTPN22. Associations were also identified between polymorphisms in genes that encode inhibitors of the pro-inflammatory transcription factor NF-kB and susceptibility to invasive pneumococcal disease and pneumococcal empyema (Chapman SJ et al., American Journal of Respiratory and Critical Care Medicine 2007; 176: 181-187). I developed a particular interest in the genetic control of the Toll-like receptor inflammatory signalling pathway, and together with a colleague Dr Khor described an association between a genetic polymorphism in the Toll adaptor protein Mal/TIRAP and protection from invasive pneumococcal disease, bacteraemia, malaria and tuberculosis (Khor CC/Chapman SJ et al., Nature Genetics 2007; 39(4): 523-528).

My clinical interests are in respiratory infection and pleural disease, and I co-authored the Oxford Handbook of Respiratory Medicine (Oxford University Press; First Edition, 2005; Reprinted, 2006; Greek, Spanish and Turkish translations, 2006; Second Edition, in progress) and have published eleven book chapters and review articles on clinical aspects of respiratory disease. My long-term goal is to pursue a career in academic respiratory medicine with the aim of translating an increased understanding of the genetic control of innate immune signalling into novel therapeutic strategies for respiratory infection.

 

Publication list

PEER-REVIEWED SCIENTIFIC PAPERS

Vannberg FO, Chapman SJ, Khor CC, Tosh K, Floyd S, Jackson-Sillah D, Crampin A, Sichali L, Bah B, Gustafson P, Aaby P, McAdam KP, Bah-Sow O, Lienhardt C, Sirugo G, Fine P, Hill AV. CD209 genetic polymorphism and tuberculosis disease. PLoS ONE. 2008 Jan 2;3(1):e1388.PMID: 18167547

Khor CC, Vannberg FO, Chapman SJ, Walley A, Aucan C , Loke H, White NJ, Peto T, Khor LK, Kwiatkowski D, Day N, Scott A, Berkley JA, Marsh K, Peshu N, Maitland K, Williams TN, Hill AVS. Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus. Genes and Immunity 2007; Aug 16 Epub ahead of print. PMID: 17703179

Chapman SJ, Khor CC, Vannberg FO, Frodsham A, Walley A, Maskell NA, Davies CWH, Segal S, Moore CE, Gillespie SH, Denny P, Day NP, Crook DW, Davies RJO, Hill AVS. IkB genetic polymorphisms and invasive pneumococcal disease. American Journal of Respiratory and Critical Care Medicine 2007; 176: 181-187. PMID: 17463416

Khor CC*/Chapman SJ*, Vannberg FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley AJ, Kyrieleis O, Khan A, Aucan C, Segal S, Moore CE, Knox K, Campbell SJ, Lienhardt C, Scott A, Aaby P, Sow OY, Grignani RT, Peshu N, Williams TN, Davies RJO, Kwiatkowski DP, Day NP, Crook DW, Marsh K, Berkley JA, O'Neill LAJ*/Hill AVS* (* these authors contributed equally to this work). A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nature Genetics 2007; 39(4): 523-528.  PMID: 17322885. Also reported as a 'Research Highlight' in Nature Reviews Immunology 2007; 7 (4): 251, Nature Reviews Microbiology 2007; 5(4): 244, Nature Medicine 2007; 13(4): 417, and in a meeting report published in Nature Immunology 2006; 7(7): 675-679.

Chapman SJ, Vannberg FO, Khor CC, Segal S, Moore CE, Knox K, Day NP, Davies RJO, Crook DW, Hill AVS. Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease. Molecular Immunology 2007; 44(12): 3267-3270. PMID: 17382393

Chapman SJ, Khor CC, Vannberg FO, Maskell NA, Davies CWH, Hedley EL, Segal S, Moore CE, Knox K, Day NP, Gillespie SH, Crook DW, Davies RJO, Hill AVS. PTPN22 and invasive bacterial disease. Nature Genetics 2006; 38(5): 499-500. PMID: 16642008

BOOKS

Chapman SJ, Robinson G, Stradling JR, West S. Oxford Handbook of Respiratory Medicine. Oxford University Press. First Edition, 2005. Reprinted, 2006. Greek, Spanish and Turkish translations, 2006.

Chapman SJ, Robinson G, Stradling JR, West S. Oxford Handbook of Respiratory Medicine. Oxford University Press. Second Edition, manuscript in preparation.

BOOK CHAPTERS

Chapman SJ, Lee YCG, Davies RJO. Empyema, lung abscess and necrotising pneumonia. Chapter in Respiratory Infections. Hodder Arnold. First Edition, 2006.

Chapman SJ, Davies RJO. Pleural effusion: parapneumonic effusion and empyema. Chapter in Encyclopedia of Respiratory Medicine. Elsevier. First Edition, 2006.

REVIEW ARTICLES

Chapman SJ. Genetic predisposition to pleural infection. International Pleural Newsletter 2007; 5(2): 9-10.

Rahman NM, Chapman SJ, Davies RJO. Diagnosis and management of infectious pleural effusion. Treatments in Respiratory Medicine 2006; 5(5): 295-304. PMID: 16928143

Rahman NM, Chapman SJ, Davies RJO. The approach to the patient with a parapneumonic effusion. Clinics in Chest Medicine 2006; 27: 253-266. PMID: 16716817

Rahman NM, Chapman SJ, Davies RJO. Pleural effusion - a structured approach to care. British Medical Bulletin 2005; 72: 31-47. PMID: 15767562

Chapman SJ, Davies RJO. Recent advances in parapneumonic effusion and empyema. Current Opinion in Pulmonary Medicine 2004; 10: 299-304. PMID: 15220756

Chapman SJ, Davies RJO. Pleural effusions. Clinical Medicine 2004; 4(3): 207-210. PMID: 15244350

Chapman SJ, Davies RJO. The management of pleural space infections. Respirology 2004; 9(1): 4-11. PMID: 14982595

Chapman SJ, Cookson WOC, Musk AW, Lee YCG. Benign asbestos-related pleural disease. Current Opinion in Pulmonary Medicine 2003; 9:266-271. PMID: 12806238

Chapman SJ, Davies CWH. Non-invasive ventilation in acute respiratory failure. Care of the Critically Ill 2003; 19(5): 145-149.