Outi Uimari

Zondervan group

Dr Outi Oumari

My research interest covers two classical benign gynaecological conditions, endometriosis and uterine fibroids. My studies focus on epidemiology, genetic epidemiology, risk factors and pathophysiology. I work as a clinical research fellow in the Nuffield Dept of Obstetrics & Gynaecology in Oxford and I am an obs&gynae trainee.

Globally endometriosis affects millions of women’s lives, causing dysmenorrhea and infertility. It is a chronic disorder of a multifactorial origin. My research focuses on investigating risk factors before the onset of this disorder, such as body size and physical activity. I am also interested in related women’s health conditions. The Northern Finland Birth Cohort study provides a good dataset for epidemiological studies on endometriosis.

Uterine fibroids cause significant morbidity to women: menorrhea, pelvic pain and pressure, and subfertility. To-date only operative treatment offers women definitive cure for fibroids. And being so, fibroids are the most common reason for hysterectomy. To offer better treatment options more discoveries are needed to reveal the etiology for uterine fibroids. My studies have concluded that inherited fibroids have a different phenotype than sporadic fibroids. The clinical picture is even more severe with women who have inherited a tumor predisposition syndrome, HLRCC. They are also in a risk for having a malignant renal tumor, so multiple uterine fibroids and strong family history might play as a precursor diagnostic tool for cancer. My aims are to reveal furthermore the risk factors and pathophysiology for uterine fibroid development from epidemiological and genetic backgrounds.

 

Publications:

1. Tolvanen J, Uimari O, Ryynänen M, Aaltonen LA, Vahteristo P. Strong family history of uterineleiomyomatosis warrants fumarate hydratase mutation screening. Human Reproduction. 2012 Jun;27(6):1865-9.

2. Uimari O, Järvelä I, Ryynänen M. Do symptomatic endometriosis and uterine fibroids appear together? Journal of Human Reproductive Sciences. 2011 Jan;4(1):34-8.

3. Uimari O, Suomalainen-König S, Säkkinen N, Santala M, Nieminen P, Ryynänen M. Natural history of familial myomas. European Journal of Obstetrics & Gynecology and Reproductive Biology.2006 Apr 1;125(2):255-8.

 

Contact details:

E-mail: outi.uimari@obs-gyn.ox.ac.uk