Functional genomics of Vitamin D
I am interested in trying to understand gene environment interactions, particularly the effects of vitamin D on genes associated with multiple sclerosis (MS) and other autoimmune conditions, and with severe sepsis.
Epidemiological evidence points towards an effect for vitamin D in the susceptibility and clinical course of several diseases. Latitude, diet, migration, month of birth, serum levels of vitamin D and other factors have been shown to influence MS. Work carried out in the Julian Knight and George Ebers groups showed a functional genetic link between vitamin D and the main susceptibility locus for MS, HLA-DRB1*1501 (Ramagopalan et al. PLoS Genetics 2009).
My research aims to elucidate the molecular mechanisms behind these interactions. My background includes a medical degree (UNAM, Mexico) and an MSc (University of Oxford). I am currently completing a DPhil as part of the Knight and Ebers labs at the University of Oxford funded by CONACyT, Mexico and the Multiple Sclerosis Societies of UK and Canada.
Keywords: Vitamin D, Multiple Sclerosis, autoimmunity