Taylor Group

Dr Dimitrios V. Vavoulis

 

Bioinformatics/Statistical Genomics

Address:

Wellcome Trust Centre for Human Genetics, Roosevelt Dr. Oxford, OX3 7BN

email twitter github

 

Work summary

I am a research scientist in the Department of Oncology (with Prof. Anna Schuh) and at the Wellcome Trust Centre for Human Genetics (with Prof. Jenny Taylor), University of Oxford, where I focus on the applications of probabilistic machine learning and Bayesian Inference for the analysis of high-throughput genomic data. I completed my PhD in Neuroscience with Prof. Paul Benjamin at the University of Sussex. Before moving to Oxford, I worked in the Computational Biology and Bioimaging Group (with Prof. Jianfeng Feng) at the University of Warwick, and in the Computational Genomics Group (with Prof. Julian Gough) at the University of Bristol. The unifying thread underlying my work has always been a keen interest in applying computational statistics methodologies for modelling and data analysis in the Life Sciences.

Selected Publications

  1. Vavoulis DV, Taylor J & Schuh A. “Hierarchical probabilistic models for multiple gene-variant associations based on next-generation sequencing data”, Bioinformatics, 2017

  2. Vavoulis DV, Frascescatto M, Heutink P & Gough J. “DGEclust: Differential expression analysis of clustered count data”, Genome Biology,doi:10.1186/s13059-015-0604-6, 2015

  3. Oates M, Stahlhacke J, Vavoulis DV, …, Gough J. The SUPERFAMILY 1.75 database in 2014: a doubling of data”, Nucleic Acids Research,doi:10.1093/nar/gku1041,2014

  4. Vavoulis DV & Gough J. “Non-parametric Bayesian modelling of digital gene expression data”. J Comput Sci Syst Biol 7:001-009. doi: 10.4172/jcsb.1000131, 2013

  5. Vavoulis DV, Straub VA, Aston JAD & Feng JF. “A self-organising state-space-model approach for parameter estimation in Hodgkin-Huxley-type models of single neurones”. PLoS Computational Biology 8(3): e1002401, 2012

  6. Vavoulis DV, Nikitin ES, Kemenes I, Feng JF, Benjamin PR & Kemenes G. “Balanced plasticity and stability of the electrical properties of a molluscan modulatory interneuron after conditioning: a computational study”. Front Behav Neurosci, 4:19 doi:10.3389/fnbeh.2010.00019, 2010

  7. Ashmole I, Vavoulis DV, Stansfeld PJ, Mehta PR, Feng JF, Sutcliffe MJ & Stanfield PR. “The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage: gating at the cytoplasmic mouth”. J Physiol, 587(20):4769-4783, 2009

  8. Nikitin ES, Vavoulis DV, Kemenes I, Marra V, Pirger Z, Michel M, Feng JF, O’Shea M, Benjamin PR & Kemenes G. “Persistent sodium current is a non-synaptic substrate for long-term associative memory”. Curr Biol 18(16): 1221-1226, 2008

  9. Vavoulis DV, Straub VA, Kemenes I, Kemenes G, Feng JF & Benjamin PR. “Dynamic control of a Central Pattern Generator circuit: a computational model of the snail feeding network”. Eur J Neurosci, 25(9): 2805-2818, 2007

For a full list of publications, check my Google Scholar profile.