Scientific Cores

In addition to their research programmes, some of our core groups offer a range of scientific services to research groups in the Centre itself, in other University of Oxford departments, and in other institutions. In addition the Centre also provides free access to a number of databases and software applications.

For more information on specific core groups, follow the links alongside or below.

Oxford Genomics Centre: High-Throughput Genomics provides

High-Throughput Sequencing (Illumina HiSeq 2000 and MiSeq)
Genotyping and Methylation Studies - Illumina, Sequenom
Expression Profiling - Illumina, Sequenom

Bioinformatics and Statistical Genetics provides

Advice and support and undertakes collaborative research with Centre staff in the areas of
Statistical genetics, eg genetic association analysis, power calculations etc
Gene annotation, including DNA and protein sequence analysis and textual data-mining
Microarrays, for gene expression, tiling arrays, CNV discovery, ChiP-chip analysis etc
Next-generation sequencing (Illumina GA-II and Roche/454 FLX), including alignment to reference genomes, SNP calling, development of new algorithms etc
Database development (eg the Integrated Genotyping System) and general programming.
Maintaining the WTCHG's scientific computing infrastructure, including numerous servers and a 1000-core cluster.

The core also carries out independent research in areas related to the Centre's activities.

Chromosome Dynamics provides

A range of different Fluorescence in situ Hybridization (FISH) applications
Related tissue culture techniques
Probe preparation
Support with cytological techniques, including Immunofluorescence and Chromogenic RNA in situ hybridization (ISH)

Cellular Imaging provides

Access to bright-field, fluorescence and confocal microscopes
Support and advice on microscopy techniques and digital imaging

Transgenics provides

Generation of genetically modified mice models
Gene targeting in embryonic stem cells
Knock-out and Knock-in construct design
Generation of Rosa26 Knock-in mice
Embryo transfer of strains for importing into the FGF
Cryopreservation of strains
Assisted reproduction

IT and Computing provides

Network infrastructure and server hosting
Email services
Network printing
Shared network storage, data archiving, backup and file recovery
Secure web hosting
Remote access facilities (Dial-up, ISDN, VPN and Windows application servers)
Network, server and workstation security
End user support