Scientific cores

In addition to their research programmes, some of our core groups offer a range of scientific services to research groups in the Centre itself, in other University of Oxford departments, and in other institutions.  In addition the Centre also provides free access to a number of databases and software applications. 

For more information on specific core groups, follow the links alongside or below.

High-Throughput Genomics

High-Throughput Genomics provides:
  • High-Throughput Sequencing (Illumina HiSeq 2000 and MiSeq)
  • Genotyping and Methylation Studies - Illumina, Sequenom
  • Expression Profiling - Illumina, Sequenom

Bioinformatics and Statistical Genetics

BSG provides advice and support, and undertakes collaborative research, in the areas of:
  • Statistical genetics, eg genetic association analysis, power calculations etc
  • Gene annotation, including DNA and protein sequence analysis and textual data-mining
  • Microarrays, for gene expression, tiling arrays, CNV discovery, ChiP-chip analysis etc
  • Next-generation sequencing (Illumina GA-II and Roche/454 FLX), including alignment to reference genomes, SNP calling, development of new algorithms etc
  • Database development (eg the Integrated Genotyping System) and general programming.
  • Maintaining the WTCHG's scientific computing infrastructure, including numerous servers and a 1000-core cluster.

The core also carries out independent research in areas related to the Centre's activities.

Chromosome Dynamics

Chromosome Dynamics provides:

  • A range of different fluorescence in situ hybridization (FISH) applications
  • Related tissue culture techniques
  • Probe preparation
  • Support with cytological techniques, including Immunofluorescence and Chromogenic RNA in situ hybridization (ISH)

Cellular Imaging

Cellular Imaging provides:

  • State-of-the-art laboratories for fluorescence microscopy and spectroscopy with technical assistance in digital imaging and quantitative microscopy applied to live cells.

  • The Cellular Imaging Core performs research and development of cutting-edge fluorescence microscopy techniques. Lifetime Imaging, Fluorescence Correlation Spectroscopy and Super-Resolution microscopy approaches are available.
  • The Cellular Imaging Core also disseminates knowledge of fluorescence spectroscopic applications to the scientific community.

Transgenics

Transgenics provides:

  • Generation of genetically modified mice models
  • Gene targeting in embryonic stem cells
  • Knock-out and Knock-in construct design
  • Generation of Rosa26 Knock-in mice
  • Embryo transfer of strains for importing into the FGF
  • Cryopreservation of strains
  • Assisted reproduction

IT and Computing

IT and Computing provide:

  • Network infrastructure and server hosting
  • Email services
  • Network printing
  • Shared network storage, data archiving, backup and file recovery
  • Secure web hosting
  • Remote access facilities (Dial-up, ISDN, VPN and Windows application servers)
  • Network, server and workstation security
  • End user support