Work Summary:

I am a programmer in Prof Peter Donnelly's group working on the Wellcome Trust Case Control Consortium 2 (WTCCC2) project. Within our group, I coordinate and manage the genome-wide association study data for 17 case and control data sets from a number of genotyping centres and make it available to the analysts. I write software in C++ and Perl for handling various formats of genotype data and converting it into a format appropriate for analysis. In particular I wrote and maintain the GTOOL package as part of the GWAS suite of software. I provide software support on our group servers and the 1152 core cluster.

Publications:

A common sequence motif associated with recombination hot spots and genome instability in humans. Myers S, Freeman C, Auton A, Donnelly P, McVean G. Nat Genet. 2008 Sep;40(9):1124-9.

The distribution and causes of meiotic recombination in the human genome. Myers S, Spencer CC, Auton A, Bottolo L, Freeman C, Donnelly P, McVean G. Biochem Soc Trans. 2006 Aug;34(Pt 4):526-30.

A fine-scale map of recombination rates and hotspots across the human genome. Myers S, Bottolo L, Freeman C, McVean G, Donnelly P. Science. 2005 Oct 14;310(5746):321-4.

Consortium Publications:

A second generation human haplotype map of over 3.1 million SNPs. International HapMap Consortium Nature. 2007 Oct 18;449(7164):851-61.

Genome-wide detection and characterization of positive selection in human populations. Sabeti et al Nature. 2007 Oct 18;449(7164):913-8.

A haplotype map of the human genome. International HapMap Consortium. Nature. 2005 Oct 27;437(7063):1299-320.