McCarthy group

Chris Groves

Laboratory manager

Address:

Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, OX3 7LJ

Email

Research overview

I graduated from the University of Wales College Swansea in 1993 with a BSC in Genetics, and started work in the Diabetes Research Laboratories (DRL) at the Radcliffe Infirmary in March 1994 where I performed immunoassays in support of the many clinical trials being run in the department at that time. I moved to the Wellcome Trust Centre for Human Genetics (WTCHG) in 1996, which at the time was based at the Nuffield Orthopaedic Centre (NOC) campus. I spent 2 years working on a Type I Diabetes microsatellite genome scan led by Professor Mark Lathrop.

In 1998 I returned to the DRL to work in the genetics lab on a complications of Type 2 diabetes project led by Professor Robert Turner and introduced techniques for both microsatellite and SNP genotyping. In early 2000 I joined Professor Mark McCarthy’s Type 2 diabetes genetics group, then based at the WTCHG (re-located to Old Road Campus), as a research assistant.

I now perform the role of Laboratory Manager at Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM), administering the laboratory space occupied by Prof McCarthy and Prof Gloyn’s groups. I facilitate the research performed by the group members, whilst contributing to our group’s research interests in several national and international consortia (CHARGE, DIAGRAM, EGG, GIANT, GoT2D, MAGIC, WTCCC). I also project manage aspects of an EU funded project (DIRECT) for which Prof McCarthy is work package lead.

Selected publications

Horikoshi M, Yaghootkar H, Mook-Kanamori DO et al. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet 2013;45:76-82.

Morris AP, Voight BF, Teslovich TM et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012;44:981-90.

Frayling TM, Timpson NJ, Weedon MN et al.  A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-94.

Groves CJ, Zeggini E, Minton J et al. Association analysis of 6,736 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006;55:2640-4.

Groves CJ, Zeggini E, Walker M et al. Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes 2006;55:1884-9.