Work Summary:

The aim of my PhD was to develop methodological tools to study the genetic component of multifactorial diseases in large pedigrees from isolated populations, these analyses being performed with high density SNP maps.

I am now involved in the Wellcome Trust Case-Control Consortium 2 (WTCCC2), and work on the population structure issue in the context of genome-wide association studies.

Publications:

Bellenguez C, Ober C, Bourgain C. (2009) Linkage Analysis with Dense SNP Maps in Isolated Populations. Hum Hered, 68:87-97

Bellenguez C, Ober C, Bourgain C. (2009) A Multiple Splitting Approach to Linkage Analysis in Large Pedigrees Identifies a Linkage to Asthma on Chromosome 12. Genet Epidemiol. 33(3):207-16

Ciullo M, Nutile T, Dalmasso C, Sorice R, Bellenguez C, Colonna V, Persico MG., Bourgain C (2008) Identification and replication of a novel obesity locus on chromosome 1q24 in isolated population of Cilento. Diabetes 57(3):793-90

Ciullo M, Bellenguez C, Colonna V, Nutile T, Calabria A, Pacente R, Iovino G, Trimarco B, Bourgain C, Persico MG. (2006) New susceptibility locus for hypertension on chromosome 8q by efficient pedigree-breaking in an Italian isolate. Hum Mol Genet 15(10):1735-1743

Research areas:

Statistical genetics, isolated populations, and population structure.

Keywords:

• Population Structure
• Association Analysis
• Isolated Populations
• Large Pedigrees
• Linkage Analysis