4. Publications and press articles - Flint Group
4.1 Publications
Chen, Y., Li, H., Li, Y., Xie, D., Wang, Z., Yang, F., . . . Deng, H. (2012, January 11). Resemblance of Symptoms for Major Depression Assessed at Interview versus from Hospital Record Review. PLOS ONE, 7. doi:10.1371/journal.pone.0028734
Webb, B. T., Guo, A. -Y., Maher, B. S., Zhao, Z., van den Oord, E. J., Kendler, K. S., . . . Hettema, J. M. (2012). Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal of Human Genetics.
Kowalczyk, M. S., Hughes, J. R., Garrick, D., Lynch, M. D., Sharpe, J. A., Sloane-Stanley, J. A., . . . Higgs, D. R. (2012). Intragenic Enhancers Act as Alternative Promoters. Molecular Cell, 45(4), 447-458.
Cong, E., Li, Y., Shao, C., Chen, J., Wu, W., Shang, X., . . . Shi, S. (2012, February). Childhood sexual abuse and the risk for recurrent major depression in Chinese women. PSYCHOLOGICAL MEDICINE, 42. doi:10.1017/S0033291711001462
Sun, N., Li, Y., Cai, Y., Chen, J., Shen, Y., Sun, J., . . . Zhang, K. (2012, January). A COMPARISON OF MELANCHOLIC AND NONMELANCHOLIC RECURRENT MAJOR DEPRESSION IN HAN CHINESE WOMEN. DEPRESSION AND ANXIETY, 29. doi:10.1002/da.20875
Wang, L., Qiao, D., Li, Y., Wang, L., Ren, J., He, K., . . . Liu, L. (2012, January). CLINICAL PREDICTORS OF FAMILIAL DEPRESSION IN HAN CHINESE WOMEN. DEPRESSION AND ANXIETY, 29. doi:10.1002/da.20878
Yang, F., Li, Y., Xie, D., Shao, C., Ren, J., Wu, W., . . . Shi, S. (2011, December). Age at onset of major depressive disorder in Han Chinese women: Relationship with clinical features and family history. JOURNAL OF AFFECTIVE DISORDERS, 135. doi:10.1016/j.jad.2011.06.056
Xia, J., He, Q., Li, Y., Xie, D., Zhu, S., Chen, J., . . . Wang, X. (2011, December). The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women. JOURNAL OF AFFECTIVE DISORDERS, 135. doi:10.1016/j.jad.2011.06.053
Tao, M., Li, Y., Xie, D., Wang, Z., Qiu, J., Wu, W., . . . Gao, J. (2011, December). Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women. JOURNAL OF AFFECTIVE DISORDERS, 135. doi:10.1016/j.jad.2011.06.054
Sang, W., Li, Y., Su, L., Yang, F., Wu, W., Shang, X., . . . Li, K. (2011, December). A comparison of the clinical characteristics of Chinese patients with recurrent major depressive disorder with and without dysthymia. JOURNAL OF AFFECTIVE DISORDERS, 135. doi:10.1016/j.jad.2011.06.051
Kowalczyk, M. S., Hughes, J. R., Garrick, D., Lynch, M. D., Sharpe, J. A., Sloane-Stanley, J. A., . . . Higgs, D. R. (2012, February 24). Intragenic enhancers act as alternative promoters.. Mol Cell, 45(4), 447-458. doi:10.1016/j.molcel.2011.12.021
Lpez-Aumatell, R., Martnez-Membrives, E., Vicens-Costa, E., Caete, T., Blzquez, G., Mont-Cardona, C., . . . Fernndez-Teruel, A. (2011). Effects of environmental and physiological covariates on sex differences in unconditioned and conditioned anxiety and fear in a large sample of genetically heterogeneous (N/Nih-HS) rats.. Behav Brain Funct, 7, 48. doi:10.1186/1744-9081-7-48
Hettema, J. M., Webb, B. T., Guo, A. -Y., Zhao, Z., Maher, B. S., Chen, X., . . . van den Oord, E. J. (2011, November 1). Prioritization and Association Analysis of Murine-Derived Candidate Genes in Anxiety-Spectrum Disorders. BIOLOGICAL PSYCHIATRY, 70. doi:10.1016/j.biopsych.2011.07.012
Cong, E., Li, Y., Shao, C., Chen, J., Wu, W., Shang, X., . . . Shi, S. (2011). Childhood sexual abuse and the risk for recurrent major depression in Chinese women. Psychological Medicine, 1-9.
Li, Y., Shi, S., Yang, F., Gao, J., Li, Y., Tao, M., . . . Zhang, Z. (2011, November 30). Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression.. Psychol Med, 1-9. doi:10.1017/S003329171100273X
Sun, N., Li, Y., Cai, Y., Chen, J., Shen, Y., Sun, J., . . . Zhang, K. (2011). A comparison of melancholic and nonmelancholic recurrent major depression in Han Chinese women. Depression and Anxiety, 4(2).
Wang, L., Qiao, D., Li, Y., Wang, L., Ren, J., He, K., . . . Liu, L. (2011). Clinical predictors of familial depression in Han Chinese women. Depression and Anxiety, 4(2).
Flint, J. (2001, March). Genetic basis of cognitive disability.. Dialogues Clin Neurosci, 3(1), 37-46.
Flint, J., Chen, Y., Shi, S., Kendler, K. S., & CONVERGE consortium. (2011, September 27). Epilogue: Lessons from the CONVERGE study of major depressive disorder in China.. J Affect Disord. doi:10.1016/j.jad.2011.09.006
Flint, J., Chen, Y., Shi, S., & Kendler, K. S. (2011). Epilogue: Lessons from the CONVERGE study of major depressive disorder in China. Journal of Affective Disorders.
Johnsen, A. K., Valdar, W., Golden, L., Ortiz-Lopez, A., Hitzemann, R., Flint, J., . . . Benoist, C. (2011, September). Genome-Wide and Species-Wide Dissection of the Genetics of Arthritis Severity in Heterogeneous Stock Mice. ARTHRITIS RHEUM-US, 63(9), 2630-2640. doi:10.1002/art.30425
Edwards, A., Treiber, C. D., Breuss, M., Pidsley, R., Huang, G. -J., Cleak, J., . . . Keays, D. A. (2011). Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse. Neuroscience.
Hettema, J. M., Webb, B. T., Guo, A. -Y., Zhao, Z., Maher, B. S., Chen, X., . . . van den Oord, E. J. (2011). Prioritization and Association Analysis of Murine-Derived Candidate Genes in Anxiety-Spectrum Disorders. Biological Psychiatry.
Munafo, M. R., & Flint, J. (2011, September). Dissecting the genetic architecture of human personality. TRENDS COGN SCI, 15(9), 395-400. doi:10.1016/j.tics.2011.07.007
Yalcin, B., Wong, K., Agam, A., Goodson, M., Keane, T. M., Gan, X. C., . . . Flint, J. (2011, September 15). Sequence-based characterization of structural variation in the mouse genome. NATURE, 477(7364), 326-329. doi:10.1038/nature10432
Keane, T. M., Goodstadt, L., Danecek, P., White, M. A., Wong, K., Yalcin, B., . . . Adams, D. J. (2011, September 15). Mouse genomic variation and its effect on phenotypes and gene regulation. NATURE, 477(7364), 289-294. doi:10.1038/nature10413
Yalcin, B., Wong, K., Agam, A., Goodson, M., Keane, T. M., Gan, X., . . . Flint, J. (2011, September 15). Sequence-based characterization of structural variation in the mouse genome.. Nature, 477(7364), 326-329. doi:10.1038/nature10432
Tian, T., Li, Y., Xie, D., Shen, Y., Ren, J., Wu, W., . . . Tian, H. (2011). Clinical features and risk factors for post-partum depression in a large cohort of Chinese women with recurrent major depressive disorder. Journal of Affective Disorders.
Sang, W., Li, Y., Su, L., Yang, F., Wu, W., Shang, X., . . . Li, K. (2011). A comparison of the clinical characteristics of Chinese patients with recurrent major depressive disorder with and without dysthymia. Journal of Affective Disorders.
Tao, M., Li, Y., Xie, D., Wang, Z., Qiu, J., Wu, W., . . . Gao, J. (2011). Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women. Journal of Affective Disorders.
Xia, J., He, Q., Li, Y., Xie, D., Zhu, S., Chen, J., . . . Wang, X. (2011). The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women. Journal of Affective Disorders.
Gan, Z., Li, Y., Xie, D., Shao, C., Yang, F., Shen, Y., . . . Zhang, J. (2011). The impact of educational status on the clinical features of major depressive disorder among Chinese women. Journal of Affective Disorders.
Munaf, M. R., & Flint, J. (2011). Dissecting the genetic architecture of human personality. Trends in Cognitive Sciences.
Munafo, M. R., & Flint, J. (2011, July). Heritability and its Discontents. EUR J PERSONALITY, 25(4), 280-282.
Edwards, A., Treiber, C. D., Breuss, M., Pidsley, R., Huang, G. J., Cleak, J., . . . Keays, D. A. (2011, November 10). Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse.. Neuroscience, 195, 191-200. doi:10.1016/j.neuroscience.2011.08.035
Yang, F., Li, Y., Xie, D., Shao, C., Ren, J., Wu, W., . . . Shi, S. (2011). Age at onset of major depressive disorder in Han Chinese women: Relationship with clinical features and family history. Journal of Affective Disorders.
Ahlqvist, E., Ekman, D., Lindvall, T., Popovic, M., Forster, M., Hultqvist, M., . . . Holmdahl, R. (2011, August 1). High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice. HUM MOL GENET, 20(15), 3031-3041. doi:10.1093/hmg/ddr206
Mathieson, I., Munaf, M. R., & Flint, J. (2011, April 12). Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.. Mol Psychiatry. doi:10.1038/mp.2011.41
Alam, I., Koller, D. L., Sun, Q., Roeder, R. K., Caete, T., Blzquez, G., . . . Foroud, T. (2011). Heterogeneous stock rat: A unique animal model for mapping genes influencing bone fragility. Bone.
Keays, D. A., Cleak, J., Huang, G. -J., Edwards, A., Braun, A., Treiber, C. D., . . . Flint, J. (2010). The role of Tuba1a in adult hippocampal neurogenesis and the formation of the dentate gyrus. Developmental Neuroscience, 32(4), 268-277.
Huang, G. J., Smith, A. L., Gray, D. H., Cosgrove, C., Singer, B. H., Edwards, A., . . . Flint, J. (2010). A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus.. PLoS Biol, 8(12), e1000561. doi:10.1371/journal.pbio.1000561
Clarke, H., Flint, J., Attwood, A. S., & Munafo, M. R. (2010, November). Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis. PSYCHOL MED, 40(11), 1767-1778. doi:10.1017/S0033291710000516
Pendola, J., Adams, D., Flint, J., Donahue, L., & Reinholdt, L. (2010, September). Inbred Mouse Strains with Complete Genome Sequences and Genetic Stability, a Powerful Tool Set for the Study of Human Disease. J AM ASSOC LAB ANIM, 49(5), 714-715.
Flint, J. (2011, February). Mapping quantitative traits and strategies to find quantitative trait genes.. Methods, 53(2), 163-174. doi:10.1016/j.ymeth.2010.07.007
Eichler, E. E., Flint, J., Gibson, G., Kong, A., Leal, S. M., Moore, J. H., . . . Nadeau, J. H. (2010, June). VIEWPOINT Missing heritability and strategies for finding the underlying causes of complex disease. NAT REV GENET, 11(6), 446-450. doi:10.1038/nrg2809
Braun, A., Breuss, M., Salzer, M. C., Flint, J., Cowan, N. J., & Keays, D. A. (2010, May 14). Tuba8 Is Expressed at Low Levels in the Developing Mouse and Human Brain. AM J HUM GENET, 86(5), 819-822. doi:10.1016/j.ajhg.2010.03.019
Billerbeck, E., Kang, Y. H., Walker, L., Lockstone, H., Grafmueller, S., Fleming, V., . . . Klenerman, P. (2010, February 16). Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.. Proc Natl Acad Sci U S A, 107(7), 3006-3011. doi:10.1073/pnas.0914839107
Yalcin, B., Nicod, J., Bhomra, A., Davidson, S., Cleak, J., Farinelli, L., . . . Flint, J. (2010, September). Commercially available outbred mice for genome-wide association studies.. PLoS Genet, 6(9). doi:10.1371/journal.pgen.1001085
Agam, A., Yalcin, B., Bhomra, A., Cubin, M., Webber, C., Holmes, C., . . . Mott, R. (2010). Elusive copy number variation in the mouse genome.. PLoS One, 5(9), e12839. doi:10.1371/journal.pone.0012839
Munaf, M. R., Durrant, C., Lewis, G., & Flint, J. (2010). Defining Replication: A Response to Kaufman and Colleagues. Biological Psychiatry, 67(4), e21-e23.
Clarke, H., Flint, J., Attwood, A. S., & Munaf, M. R. (2010). Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis. Psychological Medicine, 1-12.
Munaf, M. R., & Flint, J. (2010). How reliable are scientific studies?. British Journal of Psychiatry, 197(4), 257-258.
Lopez-Aumatell, R., Vicens-Costa, E., Guitart-Masip, M., Martinez-Membrives, E., Valdar, W., Johannesson, M., . . . Fernandez-Teruel, A. (2009, August 24). Unlearned anxiety predicts learned fear: A comparison among heterogeneous rats and the Roman rat strains. BEHAV BRAIN RES, 202(1), 92-101. doi:10.1016/j.bbr.2009.03.024
Valdar, W., Holmes, C. C., Mott, R., & Flint, J. (2009, August). Mapping in structured populations by resample model averaging.. Genetics, 182(4), 1263-1277. doi:10.1534/genetics.109.100727
Valdar, W., Holmes, C. C., Mott, R., & Flint, J. (2009, August). Mapping in Structured Populations by Resample Model Averaging. GENETICS, 182(4), 1263-1277. doi:10.1534/genetics.108.100727
Cox, A., Ackert-Bicknell, C. L., Dumont, B. L., Ding, Y., Bell, J. T., Brockmann, G. A., . . . Broman, K. W. (2009, August). A New Standard Genetic Map for the Laboratory Mouse. GENETICS, 182(4), 1335-1344. doi:10.1534/genetics.108.105486
Munafo, M. R., & Flint, J. (2009, July). Replication and heterogeneity in gene x environment interaction studies. INT J NEUROPSYCHOPH, 12(6), 727-729. doi:10.1017/S1461145709000479
Huang, G. J., Shifman, S., Valdar, W., Johannesson, M., Yalcin, B., Taylor, M. S., . . . Flint, J. (2009, June). High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.. Genome Res, 19(6), 1133-1140. doi:10.1101/gr.088120.108
Jaglin, X. H., Poirier, K., Saillour, Y., Buhler, E., Tian, G. L., Bahi-Buisson, N., . . . Chelly, J. (2009, June). Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. NAT GENET, 41(6), 746-752. doi:10.1038/ng.380
Flint, J., & Mackay, T. F. (2009, May). Genetic architecture of quantitative traits in mice, flies, and humans.. Genome Res, 19(5), 723-733. doi:10.1101/gr.086660.108
Cotton, C. H., Flint, J., & Campbell, T. G. (2009, April 2). Is there an association between NPY and neuroticism?. Nature, 458(7238), E6. doi:10.1038/nature07927
Munafo, M. R., Freimer, N. B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., . . . Flint, J. (2009, March 5). 5-HTTLPR Genotype and Anxiety-Related Personality Traits: A Meta-Analysis and New Data. AM J MED GENET B, 150B(2), 271-281. doi:10.1002/ajmg.b.30808
Bice, P., Valdar, W., Zhang, L. L., Liu, L. X., Lai, D. B., Grahame, N., . . . Foroud, T. (2009, March). Genomewide SNP Screen to Detect Quantitative Trait Loci for Alcohol Preference in the High Alcohol Preferring and Low Alcohol Preferring Mice. ALCOHOL CLIN EXP RES, 33(3), 531-537. doi:10.1111/j.1530-0277.2008.00866.x
Munafo, M. R., Stothart, G., & Flint, J. (2009, February). Bias in genetic association studies and impact factor. MOL PSYCHIATR, 14(2), 119-120. doi:10.1038/mp.2008.77
Munafo, M. R., Durrant, C., Lewis, G., & Flint, J. (2009, February 1). Gene x Environment Interactions at the Serotonin Transporter Locus. BIOL PSYCHIAT, 65(3), 211-219. doi:10.1016/j.biopsych.2008.06.009
Johannesson, M., Lopez-Aumatell, R., Stridh, P., Diez, M., Tuncel, J., Blzquez, G., . . . Flint, J. (2009, January). A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.. Genome Res, 19(1), 150-158. doi:10.1101/gr.081497.108
Lpez-Aumatel, R., Vicens-Costa, E., Guitart-Masip, M., Martnez-Membrives, E., Valda, W., Johannesson, M., . . . Fernndez-Teruel, A. (2009). Anxiety in genetically heterogeneous rats: Towards the identification of quantitative genes for behavioural traits | Ansiedad en ratas genticamente heterogneas: hacia la identificacin de genes para caracteres conductuales cuantitativos. Ansiedad y Estres, 15(1), 67-84.
Flint, J., & Mott, R. (2008, December 11). Applying mouse complex-trait resources to behavioural genetics.. Nature, 456(7223), 724-727. doi:10.1038/nature07630
Amos, W., Flint, J., & Xu, X. (2008, November 14). Heterozygosity increases microsatellite mutation rate, linking it to demographic history. BMC GENET, 9, . doi:10.1186/1471-2156-9-72
Munafo, M. R., Attwood, A. S., & Flint, J. (2008, August). Bias in genetic association studies: effects of research location and resources. PSYCHOL MED, 38(8), 1213-1214. doi:10.1017/S003329170800353X
Flint, J., & Munaf, M. R. (2008, July). Forum: Interactions between gene and environment.. Curr Opin Psychiatry, 21(4), 315-317. doi:10.1097/YCO.0b013e328306a791
Flint, J., & Shifman, S. (2008, June). Animal models of psychiatric disease.. Curr Opin Genet Dev, 18(3), 235-240. doi:10.1016/j.gde.2008.07.002
Aitman, T. J., Critser, J. K., Cuppen, E., Dominiczak, A., Fernandez-Suarez, X. M., Flint, J., . . . Worley, K. (2008, May). Progress and prospects in rat genetics: a community view. NAT GENET, 40(5), 516-522. doi:10.1038/ng.147
Fullerton, J. M., Willis-Owen, S. A., Yalcin, B., Shifman, S., Copley, R. R., Miller, S. R., . . . Flint, J. (2008, May 1). Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.. Biol Psychiatry, 63(9), 874-883. doi:10.1016/j.biopsych.2007.10.019
Mott, R., & Flint, J. (2008, May). Prospects for complex trait analysis in the mouse.. Mamm Genome, 19(5), 306-308. doi:10.1007/s00335-008-9110-4
Lopez-Aumatell, R., Guitart-Masip, M., Vicens-Costa, E., Gimenez-Llort, L., Valdar, W., Johannesson, M., . . . Femandez-Teruel, A. (2008, March 17). Fearfulness in a large N/Nih genetically heterogeneous rat stock: Differential profiles of timidity and defensive flight in males and females. BEHAV BRAIN RES, 188(1), 41-55. doi:10.1016/j.bbr.2007.10.015
Shifman, S., Bhomra, A., Smiley, S., Wray, N. R., James, M. R., Martin, N. G., . . . Flint, J. (2008, March). A whole genome association study of neuroticism using DNA pooling.. Mol Psychiatry, 13(3), 302-312. doi:10.1038/sj.mp.4002048
Shifman, S., Johannesson, M., Bronstein, M., Chen, S. X., Collier, D. A., Craddock, N. J., . . . Darvasi, A. (2008, February). Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women.. PLoS Genet, 4(2), e28. doi:10.1371/journal.pgen.0040028
Huang, G. J., Bannerman, D., & Flint, J. (2008, February). Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice. MOL PSYCHIATR, 13(2), 119-121. doi:10.1038/sj.mp.4002104
Munafo, M. R., Yalcin, B., Willis-Owen, S. A., & Flint, J. (2008, January 15). Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: Meta-analysis and new data. BIOL PSYCHIAT, 63(2), 197-206. doi:10.1016/j.biopsych.2007.04.006
Flint, J., Shifman, S., Munafo, M., & Mott, R. (2008). Genetic variants in major depression.. Novartis Found Symp, 289, 23-32.
Munafo, M. R., Attwood, A. S., & Flint, J. (2008, January). Neuregulin 1 genotype and schizophrenia. SCHIZOPHRENIA BULL, 34(1), 9-12. doi:10.1093/schbul/sbm129
Flint, J. (2008). Mapping complex traits in heterogeneous stock mice. CALCIFIED TISSUE INT, 82, S17.
Chao, M., Flint, J., Talmage, D. A., Bothwell, M., Buonanno, A., Lu, B., . . . Sklar, P. (2008). General discussion I. Novartis Foundation Symposium, 289, 87-93.
McAllister, K., Castrn, E., Lu, B., Giedd, J. N., Barde, Y. -A., Sendtner, M., . . . Talmage, D. A. (2008). Discussion. Novartis Foundation Symposium, 289, 53-59.
Chao, M., Javitt, D. C., Raff, M. C., Lu, B., Barde, Y. -A., Flint, J., . . . Buonanno, A. (2008). Discussion. Novartis Foundation Symposium, 289, 17-22.
Flint, J., Lee, F. S., Lu, B., Barde, Y. -A., Akil, H., Malaspina, D., . . . Tongiorgi, E. (2008). Discussion. Novartis Foundation Symposium, 289, 188-192.
Chao, M., Flint, J., Akil, H., Spedding, M., Sendtner, M., Malaspina, D., . . . Castrn, E. (2008). Discussion. Novartis Foundation Symposium, 289, 33-42.
Chao, M., Flint, J., Giedd, J. N., Malaspina, D., Hen, R., Spedding, M., . . . Buonanno, A. (2008). General discussion II. Novartis Foundation Symposium, 289, 193-195.
Barde, Y. -A., Lu, B., Chao, M., Akil, H., Tongiorgi, E., Lee, F. S., . . . Flint, J. (2008). Discussion. Novartis Foundation Symposium, 289, 129-135.
Chao, M., Buonanno, A., Lu, B., Flint, J., Javitt, D. C., & Talmage, D. A. (2008). Discussion. Novartis Foundation Symposium, 289, 177-179.
Munaf, M. R., Attwood, A. S., & Flint, J. (2008). Letter to the editor: Bias in genetic association studies: Effects of research location and resources. Psychological Medicine, 38(8), 1213-1214.
Raff, M. C., Giedd, J. N., Flint, J., Talmage, D. A., Castrn, E., Sendtner, M., . . . Owen, M. J. (2008). Discussion. Novartis Foundation Symposium, 289, 112-118.
Chao, M., Sklar, P., Akil, H., Owen, M. J., Brandon, N. J., & Flint, J. (2008). Discussion. Novartis Foundation Symposium, 289, 72-73.
Poirier, K., Keays, D. A., Francis, F., Saillour, Y., Bahi, N., Manouvrier, S., . . . Chelly, J. (2007, November). Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). HUM MUTAT, 28(11), 1055-1064. doi:10.1002/humu.20572
Surtees, P. G., Wainwright, N. W. J., Willis-Owen, S. A. G., Sandhu, M. S., Luben, R., Day, N. E., . . . Flint, J. (2007, October). The brain-derived neurotrophic factor Val66Met polymorphism is associated with sense of coherence in a non-clinical community sample of 7335 adults. J PSYCHIATR RES, 41(8), 707-710. doi:10.1016/j.jpsychires.2006.05.015
Goldacre, M. J., Wotton, C. J., Yeates, D., Seagroatt, V., & Flint, J. (2007, September). Cancer in people with depression or anxiety: record-linkage study.. Soc Psychiatry Psychiatr Epidemiol, 42(9), 683-689. doi:10.1007/s00127-007-0211-2
Surtees, P. G., Wainwright, N. W. J., Willis-Owen, S. A. G., Sandhu, M. S., Luben, R., Day, N. E., . . . Flint, J. (2007, August). No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J PSYCHIATR RES, 41(5), 404-409. doi:10.1016/j.jpsychires.2006.01.004
Taylor, M., Valdar, W., Kumar, A., Flint, J., & Mott, R. (2007, June 15). Management, presentation and interpretation of genome scans using GSCANDB.. Bioinformatics, 23(12), 1545-1549. doi:10.1093/bioinformatics/btm123
Martin, J., Cleak, J., Willis-Owen, S. A. G., Flint, J., & Shifman, S. (2007, May). Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. MOL PSYCHIATR, 12(5), 421-422. doi:10.1038/sj.mp.4001952
Munafo, M. R., Matheson, I. J., & Flint, J. (2007, May). Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias. MOL PSYCHIATR, 12(5), 454-461. doi:10.1038/sj.mp.4001938
Shifman, S., Bell, J. T., Copley, R. R., Taylor, M. S., Williams, R. W., Mott, R., . . . Flint, J. (2007, May). Evidence of a large-scale functional organization of mammalian chromosomes: Authors' reply. PLOS BIOL, 5(5), 984. doi:10.1371/journal.pbio.0050128
Flint, J., & Munaf, M. R. (2007, February). The endophenotype concept in psychiatric genetics.. Psychol Med, 37(2), 163-180. doi:10.1017/S0033291706008750
Keays, D. A., Tian, G., Poirier, K., Huang, G. J., Siebold, C., Cleak, J., . . . Flint, J. (2007, January 12). Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans.. Cell, 128(1), 45-57. doi:10.1016/j.cell.2006.12.017
Willis-Owen, S. A., & Flint, J. (2007). Identifying the genetic determinants of emotionality in humans; insights from rodents.. Neurosci Biobehav Rev, 31(1), 115-124. doi:10.1016/j.neubiorev.2006.07.006
Leygraf, A., Hohoff, C., Freitag, C., Willis-Owen, S. A. G., Krakowitzky, P., Fritze, J., . . . Deckert, J. (2006, December). Rgs 2 gene polymorphisms as modulators of anxiety in humans?. J NEURAL TRANSM, 113(12), 1921-1925. doi:10.1007/s00702-006-0484-8
Shifman, S., Bell, J. T., Copley, R. R., Taylor, M. S., Williams, R. W., Mott, R., . . . Flint, J. (2006, November). A high-resolution single nucleotide polymorphism genetic map of the mouse genome.. PLoS Biol, 4(12), e395. doi:10.1371/journal.pbio.0040395
Valdar, W., Solberg, L. C., Gauguier, D., Cookson, W. O., Rawlins, J. N. P., Mott, R., . . . Flint, J. (2006, October). Genetic and environmental effects on complex traits in mice. GENETICS, 174(2), 959-984. doi:10.1534/genetics.106.060004
Valdar, W., Solberg, L. C., Gauguier, D., Burnett, S., Klenerman, P., Cookson, W. O., . . . Flint, J. (2006, August). Genome-wide genetic association of complex traits in heterogeneous stock mice.. Nat Genet, 38(8), 879-887. doi:10.1038/ng1840
Willis-Owen, S. A., & Flint, J. (2006, June). The genetic basis of emotional behaviour in mice.. Eur J Hum Genet, 14(6), 721-728. doi:10.1038/sj.ejhg.5201569
Munafo, M. R., Thiselton, D. L., Clark, T. G., & Flint, J. (2006, June). Association of the NRG1 gene and schizophrenia: a meta-analysis. MOL PSYCHIATR, 11(6), 539-546. doi:10.1038/sj.mp.4001817
Flint, J., & Monaco, A. P. (2006, June). Focus on behavioural genetics. EUR J HUM GENET, 14(6), 647-648. doi:10.1038/sj.ejhg.5201599
Valdar, W., Flint, J., & Mott, R. (2006, March). Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice.. Genetics, 172(3), 1783-1797. doi:10.1534/genetics.104.039313
Keays, D. A., Clark, T. G., & Flint, J. (2006, March). Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.. Mamm Genome, 17(3), 230-238. doi:10.1007/s00335-005-0101-4
Aitman, T. J., Dong, R., Vyse, T. J., Norsworthy, P. J., Johnson, M. D., Smith, J., . . . Cook, H. T. (2006, February 16). Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. NATURE, 439(7078), 851-855. doi:10.1038/nature04489
Solberg, L. C., Valdar, W., Gauguier, D., Nunez, G., Taylor, A., Burnett, S., . . . Flint, J. (2006, February). A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice.. Mamm Genome, 17(2), 129-146. doi:10.1007/s00335-005-0112-1
Willis-Owen, S. A. G., Shifman, S., Copley, R. R., & Flint, J. (2006, February). DCNP1: a novel candidate gene for major depression. MOL PSYCHIATR, 11(2), 121-122. doi:10.1038/sj.mp.4001747
Surtees, P. G., Wainwright, N. W. J., Willis-Owen, S. A. G., Luben, R., Day, N. E., & Flint, J. (2006, February 1). Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. BIOL PSYCHIAT, 59(3), 224-229. doi:10.1016/j.biopsych.2005.07.014
Munafo, M. R., Lee, L., Ayres, R., Flint, J., Goodwin, G., & Harmer, C. J. (2006, January). Early morning salivary cortisol is not associated with extraversion. PERS INDIV DIFFER, 40(2), 395-400. doi:10.1016/j.paid.2005.06.028
Shifman, S., Bell, J. T., Copley, R. R., Taylor, M. S., Williams, R. W., Mott, R., . . . Flint, J. (2006). A high-resolution single nucleotide polymorphism genetic map of the mouse genome.. PLoS biology, 4(12).
Shevell, M., Ashwal, S., Donley, D., Flint, J., Gingold, M., Hirtz, D., . . . Edlund, W. (2006). Appendix B: Practice parameter: Evaluation of the child with global developmental delay. CONTINUUM Lifelong Learning in Neurology, 12(5), 111-124.
Willis-Owen, S. A., Fullerton, J., Surtees, P. G., Wainwright, N. W., Miller, S., & Flint, J. (2005, November 1). The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism.. Biol Psychiatry, 58(9), 738-742. doi:10.1016/j.biopsych.2005.05.014
Yalcin, B., Flint, J., & Mott, R. (2005, October). Using progenitor strain information to identify quantitative trait nucleotides in outbred mice.. Genetics, 171(2), 673-681. doi:10.1534/genetics.104.028902
Munafo, M. R., Clark, T., & Flint, J. (2005, October). Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Schinka. MOL PSYCHIATR, 10(10), 895-897. doi:10.1038/sj.mp.4001706
Willis-Owen, S. A., Turri, M. G., Munaf, M. R., Surtees, P. G., Wainwright, N. W., Brixey, R. D., . . . Flint, J. (2005, September 15). The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association.. Biol Psychiatry, 58(6), 451-456. doi:10.1016/j.biopsych.2005.04.050
Munaf, M. R., Bowes, L., Clark, T. G., & Flint, J. (2005, August). Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies.. Mol Psychiatry, 10(8), 765-770. doi:10.1038/sj.mp.4001664
Munafo, M. R., Wileyto, E. P., & Flint, J. (2005, May). Response to Manly: Statistical stringency in tests of genetic association - implications for sample size and study design. TRENDS GENET, 21(5), 269-271. doi:10.1016/j.tig.2005.03.003
Munaf, M. R., Clark, T., & Flint, J. (2005, April). Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis.. Mol Psychiatry, 10(4), 415-419. doi:10.1038/sj.mp.4001627
Portella, M. J., Harmer, C. J., Flint, J., Cowen, P., & Goodwin, G. M. (2005, April). Enhanced early morning salivary cortisol in neuroticism.. Am J Psychiatry, 162(4), 807-809. doi:10.1176/appi.ajp.162.4.807
Flint, J., Valdar, W., Shifman, S., & Mott, R. (2005, April). Strategies for mapping and cloning quantitative trait genes in rodents.. Nat Rev Genet, 6(4), 271-286. doi:10.1038/nrg1576
Price, T. S., Regan, R., Mott, R., Hedman, A., Honey, B., Daniels, R. J., . . . Knight, S. J. (2005). SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data.. Nucleic Acids Res, 33(11), 3455-3464. doi:10.1093/nar/gki643
Manly, K. F., Munaf, M. R., Wileyto, E. P., & Flint, J. (2005). Conventional P-values fail to assure reproducibility for genetic association tests (multiple letters). Trends in Genetics, 21(5), 268-271.
Schinka, J. A., Sen, S., Burmeister, M., Ghosh, D., Munaf, M. R., Clark, T., . . . Flint, J. (2005). Measurement scale does moderate the association between the serotonin transporter gene and trait anxiety: Comments on Munafo et al [1] (multiple letters). Molecular Psychiatry, 10(10), 892-897.
Munaf, M. R., Clark, T. G., & Flint, J. (2004, November 30). Assessing publication bias in genetic association studies: evidence from a recent meta-analysis.. Psychiatry Res, 129(1), 39-44. doi:10.1016/j.psychres.2004.06.011
Rawlins, J. N., Fullerton J., Willis-Owen SA., & Yalcin B. (2004, November). Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.. Nature Genetics, 36(11), 1197-1202. doi:10.1038/ng1450
Bogani, D., Warr, N., Elms, P., Davies, J., Tymowska-Lalanne, Z., Goldsworthy, M., . . . Arkell, R. (2004, October). New semidominant mutations that affect mouse development. GENESIS, 40(2), 109-117. doi:10.1002/gene.20071
Munaf, M. R., & Flint, J. (2004, September). Meta-analysis of genetic association studies.. Trends Genet, 20(9), 439-444. doi:10.1016/j.tig.2004.06.014
Munafo, M. R., Clark, T. G., & Flint, J. (2004, August). Are there sex differences in the association between the 5HTT gene and neuroticism? A meta-analysis. PERS INDIV DIFFER, 37(3), 621-626. doi:10.1016/j.paid.2003.09.031
Stewart, D. R., Huang, A., Faravelli, F., Anderlid, B. M., Medne, L., Ciprero, K., . . . Krantz, I. D. (2004, August 1). Subtelomeric deletions of chromosome 9q: A novel microdeletion syndrome. AM J MED GENET A, 128A(4), 340-351. doi:10.1002/ajmg.a.30136
Khoo, J. P., Nicoli, T., Alp, N. J., Fullerton, J., Flint, J., & Channon, K. M. (2004, July). Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.. Mol Genet Metab, 82(3), 251-254. doi:10.1016/j.ymgme.2004.04.006
Yalcin, B., Fullerton, J., Miller, S., Keays, D. A., Brady, S., Bhomra, A., . . . Mott, R. (2004, June 29). Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice.. Proc Natl Acad Sci U S A, 101(26), 9734-9739. doi:10.1073/pnas.0401189101
Flint, J. (2004, May). The genetic basis of neuroticism.. Neurosci Biobehav Rev, 28(3), 307-316. doi:10.1016/j.neubiorev.2004.01.004
Henderson, N. D., Turri, M. G., DeFries, J. C., & Flint, J. (2004, May). QTL analysis of multiple behavioral measures of anxiety in mice. BEHAV GENET, 34(3), 267-293.
Turri, M. G., DeFries, J. C., Henderson, N. D., & Flint, J. (2004, February). Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice.. Mamm Genome, 15(2), 69-76.
Flint, J., DeFries, J. C., & Henderson, N. D. (2004, February). Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice.. Mamm Genome, 15(2), 77-82.
Knight, S. J., & Flint, J. (2004). The use of subtelomeric probes to study mental retardation.. Methods Cell Biol, 75, 799-831.
Valdar, W. S., Flint, J., & Mott, R. (2003, December). QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks.. Mamm Genome, 14(12), 830-838. doi:10.1007/s00335-003-3021-1
Hitzemann, R., Malmanger, B., Reed, C., Lawler, M., Hitzemann, B., Coulombe, S., . . . Talbot, C. (2003, November). A strategy for the integration of QTL, gene expression, and sequence analyses. MAMM GENOME, 14(11), 733-747. doi:10.1007/s00335-003-2277-9
Adiga, P. S. U., & Flint, J. (2003, October). An efficient tool for genetic experiments: agarose gel image analysis. PATTERN RECOGN, 36(10), 2453-2461. doi:10.1016/S0031-3203(03)00129-8
Flint, J., & Knight, S. (2003, June). The use of telomere probes to investigate submicroscopic rearrangements associated with mental retardation.. Curr Opin Genet Dev, 13(3), 310-316.
Munaf, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., & Flint, J. (2003, May). Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis.. Mol Psychiatry, 8(5), 471-484. doi:10.1038/sj.mp.4001326
Aguilar, R., Gil, L., Gray, J. A., Driscoll, P., Flint, J., Dawson, G. R., . . . Tobena, A. (2003, April). Fearfulness and sex in F2 Roman rats: males display more fear though both sexes share the same fearfulness traits. PHYSIOL BEHAV, 78(4-5), 723-732. doi:10.1016/S0031-9384(03)00043-X
Fullerton, J., Cubin, M., Tiwari, H., Wang, C., Bomhra, A., Davidson, S., . . . Flint, J. (2003, April). Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.. Am J Hum Genet, 72(4), 879-890. doi:10.1086/374178
Talbot, C. J., Radcliffe, R. A., Fullerton, J., Hitzemann, R., Wehner, J. M., & Flint, J. (2003, April). Fine scale mapping of a genetic locus for conditioned fear. MAMM GENOME, 14(4), 223-230. doi:10.1007/s00335-002-3059-5
Steinberger, D., Reynolds, D. S., Ferris, P., Lincoln, R., Datta, S., Stanley, J., . . . Flint, J. (2003, March 15). Genetic mapping of variation in spatial learning in the mouse.. J Neurosci, 23(6), 2426-2433.
Brownlie, A., Hersey, C., Oates, A. C., Paw, B. H., Falick, A. M., Witkowska, H. E., . . . Zon, L. (2003, March 1). Characterization of embryonic globin genes of the zebrafish. DEV BIOL, 255(1), 48-61. doi:10.1016/S0012-1606(02)00041-6
Shevell, M., Ashwal, S., Donley, D., Flint, J., Gingold, M., Hirtz, D., . . . Sheth, R. D. (2003, February 11). Practice parameter: Evaluation of the child with global developmental delay - Report of the quality standards subcommittee of the American Academy of Neurology and The Practice Committee of the Child Neurology Society. NEUROLOGY, 60(3), 367-380.
Flint, J. (2003, February). Animal models of anxiety and their molecular dissection.. Semin Cell Dev Biol, 14(1), 37-42.
Flint, J. (2003, January). Analysis of quantitative trait loci that influence animal behavior.. J Neurobiol, 54(1), 46-77. doi:10.1002/neu.10161
Hitzemann, R., Malmanger, B., Cooper, S., Coulombe, S., Reed, C., Demarest, K., . . . McCaughran, J. (2002, November). Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation. GENES BRAIN BEHAV, 1(4), 214-222.
Flint, J., Fernandez-Teruel, A., Escorihuela, R. M., Gray, J. A., Aguilar, R., Gil, L., . . . Dawson, G. R. (2002, November). A quantitative trait locus influencing anxiety in the laboratory rat. BEHAV GENET, 32(6), 464.
Henderson, N. D., Turri, M. G., DeFries, J. C., & Flint, J. (2002, November). Sex differences in QTLs operating on multiple behavioral assessments of anxiety in laboratory mice.. BEHAV GENET, 32(6), 469.
Turri, M. G., DeFries, J. C., Henderson, N. D., & Flint, J. (2002, November). Multivariate and epistatic interaction analysis of multiple behavioral dimensions in ethological tests of anxiety in laboratory mice.. BEHAV GENET, 32(6), 486.
Flint, J. (2002, October 2). Genetic effects on an animal model of anxiety.. FEBS Lett, 529(1), 131-134.
Bannerman, D. M., Rawlins JN., Reisel D., & Schmitt WB. (2002, September). Spatial memory dissociations in mice lacking GluR1.. Nature neuroscience., 5(9), 868-873. doi:10.1038/nn910
Fernandez-Teruel, A., Escorihuela, R. M., Gray, J. A., Aguilar, R., Gil, L., Gimenez-Llort, L., . . . Flint, J. (2002, April). A quantitative trait locus influencing anxiety in the laboratory rat. GENOME RES, 12(4), 618-626. doi:10.1101/gr.203402
Mott, R., & Flint, J. (2002, April). Simultaneous detection and fine mapping of quantitative trait loci in mice using heterogeneous stocks.. Genetics, 160(4), 1609-1618.
Nokelainen, P., & Flint, J. (2002, March). Genetic effects on human cognition: lessons from the study of mental retardation syndromes.. J Neurol Neurosurg Psychiatry, 72(3), 287-296.
Aguilar, R., Gil, L., Flint, J., Gray, J. A., Dawson, G. R., Driscoll, P., . . . Tobena, A. (2002, January 1). Learned fear, emotional reactivity and fear of heights: A factor analytic map from a large F-2 intercross of Roman rat strains. BRAIN RES BULL, 57(1), 17-26.
Knight, S. J., & Flint, J. (2002). Multi-telomere FISH.. Methods Mol Biol, 204, 155-179. doi:10.1385/1-59259-300-3:155
Flint, J. (2001, November 13). Psychiatric genetics: a frightful chromosome.. Curr Biol, 11(22), R907-R909.
Adiga, P. S., Bhomra, A., Turri, M. G., Nicod, A., Datta, S. R., Jeavons, P., . . . Flint, J. (2001, November). Automatic analysis of agarose gel images.. Bioinformatics, 17(11), 1084-1089.
Flint, J. (2001, November). Is this mouse anxious? The difficulties of interpreting the effects of genetic action. Commentary on Belzung "The genetic basis of the pharmacological effects of anxiolytics" and Olivier et al. "The 5-HT(1A) receptor knockout mouse and anxiety".. Behav Pharmacol, 12(6-7), 461-465.
Nokelainen, P., Heiskala, H., Raininko, R., Autti, T., Wirtavuori, K., Hkkinen, A. M., . . . Flint, J. (2001, October 15). Two brothers with macrocephaly, progressive cerebral atrophy and abnormal white matter, severe mental retardation, and Lennox-Gastaut spectrum type epilepsy: an inherited encephalopathy of childhood?. Am J Med Genet, 103(3), 198-206.
Faith, M. S., Flint, J., Fairburn, C. G., Goodwin, G. M., & Allison, D. B. (2001, October). Gender differences in the relationship between personality dimensions and relative body weight. OBES RES, 9(10), 647-650.
Flint, J. (2001, September). Anxious genes: pitfalls in mapping the genetic basis of behaviour. J MED GENET, 38, S27.
Turri, M. G., Henderson, N. D., DeFries, J. C., & Flint, J. (2001, July). Quantitative trait locus mapping in laboratory mice derived from a replicated selection experiment for open-field activity.. Genetics, 158(3), 1217-1226.
Sismani, C., Armour, J. A. L., Flint, J., Girgalli, C., Regan, R., & Patsalis, P. C. (2001, July). Screening for subtelomeric chromosome abnormalities in children with idiopathic mental retardation using multiprobe telomeric FISH and the new MAPH telomeric assay. EUR J HUM GENET, 9(7), 527-532.
Flint, J., & Mott, R. (2001, June). Finding the molecular basis of quantitative traits: successes and pitfalls.. Nat Rev Genet, 2(6), 437-445. doi:10.1038/35076585
Turri, M. G., Datta, S. R., DeFries, J., Henderson, N. D., & Flint, J. (2001, May 15). QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice.. Curr Biol, 11(10), 725-734.
Paterson, A., Whiting, P. J., Gray, J. A., Flint, J., & Dawson, G. R. (2001, April). Lack of consistent behavioural effects of Maudsley reactive and non-reactive rats in a number of animal tests of anxiety and activity. PSYCHOPHARMACOLOGY, 154(4), 336-342.
de Vries, B. B. A., Lees, M., Knight, S. J. L., Regan, R., Corney, D., Flint, J., . . . Winter, R. M. (2001, April 1). Submicroscopic 8pter deletion, mild mental retardation, and behavioral problems caused by a familial t(8;20)(p23;p13). AM J MED GENET, 99(4), 314-319.
Flint, J. (2001, March). Not all behaviour can be mapped. PSYCHOLOGIST, 14(3), 142-143.
de Vries, B. B. A., White, S. M., Knight, S. J. L., Regan, R., Homfray, T., Young, I. D., . . . Winter, R. M. (2001, March). Clinical studies on submicroscopic subtelomeric rearrangements: a checklist. J MED GENET, 38(3), 145-150.
De Vries, B. B. A., Knight, S. J. L., Homfray, T., Smithson, S. F., Flint, J., & Winter, R. M. (2001, March). Submicroscopic subtelomeric 1qter deletions: a recognisable phenotype?. J MED GENET, 38(3), 175-178.
Daniels, R. J., Peden, J. F., Lloyd, C., Horsley, S. W., Clark, K., Tufarelli, C., . . . Higgs, D. R. (2001, February 15). Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.. Hum Mol Genet, 10(4), 339-352.
Flint, J., Tufarelli, C., Peden, J., Clark, K., Daniels, R. J., Hardison, R., . . . Higgs, D. R. (2001, February 15). Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the alpha globin cluster.. Hum Mol Genet, 10(4), 371-382.
Riethman, H. C., Xiang, Z., Paul, S., Morse, E., Hu, X. L., Flint, J., . . . Moyzis, R. K. (2001, February 15). Integration of telomere sequences with the draft human genome sequence. NATURE, 409(6822), 948-951.
Xiang, Z., Morse, E., Hu, X. L., Flint, J., Chi, H. C., Grady, D. L., . . . Riethman, H. C. (2001, February 15). A sequence-ready map of the human chromosome 1q telomere. GENOMICS, 72(1), 105-107.
Tufarelli, C., Frischauf, A. M., Hardison, R., Flint, J., & Higgs, D. R. (2001, February 1). Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.. Genomics, 71(3), 307-314. doi:10.1006/geno.2000.6394
Martin, N., Goodwin, G., Fairburn, C., Wilson, R., Allison, D., Cardon, L. R., . . . Flint, J. (2000, December). A population-based study of personality in 34,000 sib-pairs.. Twin Res, 3(4), 310-315.
de Vries, B. B. A., Bitner-Glindzicz, M., Knight, S. J. L., Tyson, J., MacDermot, K. D., Flint, J., . . . Winter, R. M. (2000, December). A boy with a submicroscopic 22qter deletion, general overgrowth and features suggestive of FG syndrome. CLIN GENET, 58(6), 483-487.
Knight, S. J. L., & Flint, J. (2000, November 18). Screening chromosome ends for learning disability - Small chromosomal rearrangements may be behind idiopathic learning disability. BRIT MED J, 321(7271), 1240.
Mott, R., Talbot, C. J., Turri, M. G., Collins, A. C., & Flint, J. (2000, November 7). A method for fine mapping quantitative trait loci in outbred animal stocks.. Proc Natl Acad Sci U S A, 97(23), 12649-12654. doi:10.1073/pnas.230304397
Shannon, N. L., Regan, R., Maltby, E. L., Flint, J., Rigby, A. S., Hall, D. M. B., . . . Quarrell, O. W. J. (2000, October). Wolf-Hirschhorn Syndrome: developmental outcome and mortality correlate with deletion size.. AM J HUM GENET, 67(4), 124.
Martin, N. C., Cardon, L. R., & Flint, J. (2000, September). Population-based survey of the EPQ in southern England. BEHAV GENET, 30(5), 412.
Knight, S. J., Lese, C. M., Precht, K. S., Kuc, J., Ning, Y., Lucas, S., . . . Flint, J. (2000, August). An optimized set of human telomere clones for studying telomere integrity and architecture.. Am J Hum Genet, 67(2), 320-332. doi:10.1086/302998
Knight, S. J., & Flint, J. (2000, June). Perfect endings: a review of subtelomeric probes and their use in clinical diagnosis.. J Med Genet, 37(6), 401-409.
Knight-Jones, E., Knight, S., Heussler, H., Regan, R., Flint, J., & Martin, K. (2000, March). Neurodevelopmental profile of a new dysmorphic syndrome associated with submicroscopic partial deletion of 1p36.3. DEV MED CHILD NEUROL, 42(3), 201-206.
Turri, M. G., Datta, S., Henderson, N., DeFries, J., & Flint, J. (2000). QTL analysis of fear related behaviour in mice.. EUR J NEUROSCI, 12, 103.
Gil, L., Aguilar, R., Gimenez-Llort, L., Flint, J., Tobena, A., Driscoll, P., . . . Escorihuela, R. M. (2000). Multifactorial and genetic analysis of exploration, anxiety, conditioned fear and aversive instrumental learning in rats.. EUR J NEUROSCI, 12, 105.
Flint, J., Paterson, A., Dawson, G., Escorihuela, G. R. M., Aguilar, R., Gill, L., . . . Tobena, A. (2000). Mapping QTLS for conditioned fear in the Roman High and Low avoidance strains. EUR J NEUROSCI, 12, 311.
Flint, J. (2000). The value of animals models of human behavioural disorders. EUR J NEUROSCI, 12, 514.
Flint, J., Bond, J., Rees, D. C., Boyce, A. J., Roberts-Thomson, J. M., Excoffier, L., . . . Harding, R. M. (1999, December). Minisatellite mutational processes reduce F(st) estimates.. Hum Genet, 105(6), 567-576.
Knight, S. J., Regan, R., Nicod, A., Horsley, S. W., Kearney, L., Homfray, T., . . . Flint, J. (1999, November 13). Subtle chromosomal rearrangements in children with unexplained mental retardation.. Lancet, 354(9191), 1676-1681. doi:10.1016/S0140-6736(99)03070-6
Flint, J. (1999, November). The genetic basis of cognition.. Brain, 122 ( Pt 11), 2015-2032.
Turri, M. G., Talbot, C. J., Radcliffe, R. A., Wehner, J. M., & Flint, J. (1999, November). High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice.. Mamm Genome, 10(11), 1098-1101.
Flint, J. (1999, November). The genetic basis of cognition. BRAIN, 122, 2015-2031.
Nokelainen, P. T., Quarrell, O., Kerr, B., Regan, R., & Flint, J. (1999, October). Detection of two chromosomal arrangements in the subtelomeric region of 9q in mentally retarded children.. AM J HUM GENET, 65(4), A352.
Dawson, G. R., Flint, J., & Wilkinson, L. S. (1999, September 24). Testing the genetics of behavior in mice. SCIENCE, 285(5436), 2068.
Regan, R., Knight, S. J. L., Nicod, A., Lucas, S., Horsley, S., Kearney, L., . . . Flint, J. (1999, September). Subtelomeric rearrangements and idiopathic mental retardation. J MED GENET, 36, S22.
Xiang, Z., Hu, X. L., Flint, J., & Riethman, H. C. (1999, June 1). A sequence-ready map of the human chromosome 17p telomere. GENOMICS, 58(2), 207-210.
Brackley, K. J., Kilby, M. D., Morton, J., Whittle, M. J., Knight, S. J. L., & Flint, J. (1999, June). A case of recurrent congenital fetal anomalies associated with a familial subtelomeric translocation. PRENATAL DIAG, 19(6), 570-574.
Flint, J., & Goodwin, G. (1999, May 6). Psychiatric genetics: a genetic basis for health?. Curr Biol, 9(9), R326-R328.
Slavotinek, A., Rosenberg, M., Knight, S., Gaunt, L., Fergusson, W., Killoran, C., . . . Biesecker, L. (1999, May). Screening for submicroscopic chromosome rearrangements in children with idiopathic mental retardation using microsatellite markers for the chromosome telomeres. J MED GENET, 36(5), 405-411.
Talbot, C. J., Nicod, A., Cherny, S. S., Fulker, D. W., Collins, A. C., & Flint, J. (1999, March). High-resolution mapping of quantitative trait loci in outbred mice.. Nat Genet, 21(3), 305-308. doi:10.1038/6825
Talbot, C. J., Nicod, A., Cherney, S., Fulker, D., Collins, A., & Flint, J. (1998, October 26). Ultra-fine mapping of quantitative trait loci (QTLs). BRAIN RES, 809(1), A21.
Brenan, M., & Flint, J. (1998, October). Examination of the X chromosome by STS-PCR screening for the presence of submicroscopic deletions.. Hum Genet, 103(4), 488-492.
Flint, J. (1998). New approaches to cloning QTLs for complex behaviours using animal models. EUR J NEUROSCI, 10, 327.
Horsley, S. W., Knight, S. J., Nixon, J., Huson, S., Fitchett, M., Boone, R. A., . . . Kearney, L. (1998, September). Del(18p) shown to be a cryptic translocation using a multiprobe FISH assay for subtelomeric chromosome rearrangements.. J Med Genet, 35(9), 722-726.
Flint, J. (1998, May 8). Behavioral phenotypes: conceptual and methodological issues.. Am J Med Genet, 81(3), 235-240.
Flint, J., Sims, M., Clark, K., Staden, R., & Thomas, K. (1998, March). An oligo-screening strategy to fill gaps found during shotgun sequencing projects.. DNA Seq, 8(4), 241-245.
Flint, J., Harding, R. M., Boyce, A. J., & Clegg, J. B. (1998, March). The population genetics of the haemoglobinopathies.. Baillieres Clin Haematol, 11(1), 1-51.
Kearney, L., Knight, S. J. L., Horsley, S. W., Regan, R., & Flint, J. (1998). Human subtelomeric probes: applications in practice. EUR J HUM GENET, 6, 23-24.
Slavotinek, A., Rosenberg, M., Knight, S., Fergusson, W., Gaunt, L., Clayton-Smith, J., . . . Donnai, D. (1998). The detection of submicroscopic chromosome rearrangements in children with idiopathic mental retardation and physical differences. EUR J HUM GENET, 6, 91.
Flint, J. (1997, November). Freeze!. NAT GENET, 17(3), 250-251.
Hewitt, J. E., Bolland, D., Flint, J., & Dickson, M. C. (1997, October). Inter- and intrachromosomal duplications of distal chromosome 4q35; an example of telomere plasticity.. AM J HUM GENET, 61(4), A38.
Lese, C. M., Fantes, J. A., Precht, K. S., Killos, L. D., Stanley, W. S., Hirsch, B., . . . Ledbetter, D. H. (1997, October). Molecular characterization of human telomeres: extension of integrated physical maps and strategies for genotype-phenotype correlations.. AM J HUM GENET, 61(4), A131.
Knight, S. J. L., Regan, R., Flint, J., Horsley, S. W., Kearney, L., Temple, I. K., . . . Young, I. D. (1997, October). Identification of a submicroscopic familial 4p;11p translocation using multiple telomere probe FISH analysis. AM J HUM GENET, 61(4), A144.
Talbot, C. J., Nicod, A., Cherney, S., Fulker, D., Collins, A., & Flint, J. (1997, October). Fine mapping of QTLs for emotionally in mice as a model of human anxiety.. AM J HUM GENET, 61(4), A296.
Slavotinek, A., Knight, S. J. L., Tassabehji, M., ClaytonSmith, J., Kingston, H., Gaunt, L., . . . Donnai, D. (1997, September). Screening for subtelomeric chromosome deletions in children with idiopathic mental retardation. J MED GENET, 34, 1206.
Rosenberg, M., Hui, L., Ma, J. L., Nusbaum, H. C., Clark, K., Robinson, L., . . . Flint, J. (1997, September). Characterization of short tandem repeats from thirty-one human telomeres. GENOME RES, 7(9), 917-923.
Flint, J., Bates, G. P., Clark, K., Dorman, A., Willingham, D., Roe, B. A., . . . Louis, E. J. (1997, August). Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains.. Hum Mol Genet, 6(8), 1305-1313.
Aitman, T. J., Gotoda, T., Evans, A. L., Imrie, H., Heath, K. E., Trembling, P. M., . . . Scott, J. (1997, June). Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. NAT GENET, 16(2), 197-201.
Giraudeau, F., Aubert, D., Young, I., Horsley, S., Knight, S., Kearney, L., . . . Flint, J. (1997, April). Molecular-cytogenetic detection of a deletion of 1p36.3. J MED GENET, 34(4), 314-317.
Flint, J., Thomas, K., Micklem, G., Raynham, H., Clark, K., Doggett, N. A., . . . Higgs, D. R. (1997, March). The relationship between chromosome structure and function at a human telomeric region.. Nat Genet, 15(3), 252-257. doi:10.1038/ng0397-252
Knight, S. J., Horsley, S. W., Regan, R., Lawrie, N. M., Maher, E. J., Cardy, D. L., . . . Kearney, L. (1997, January). Development and clinical application of an innovative fluorescence in situ hybridization technique which detects submicroscopic rearrangements involving telomeres.. Eur J Hum Genet, 5(1), 1-8.
Wong, A. C. C., Ning, Y., Flint, J., Clark, K., Dumanski, J. P., Ledbetter, D. H., . . . McDermid, H. E. (1997, January). Molecular characterization of a 130-kb terminal microdeletion at 22q in a child with mild mental retardation. AM J HUM GENET, 60(1), 113-120.
Horsley, S., Knight, S. J., Regan, R., Cardy, D. L. N., Lawrie, N. M., Flint, J., . . . Kearney, L. (1997). A fluorescence in situ hybridisation (FISH) assay for submicroscopic chromosome rearrangements involving telomers.. CYTOGENET CELL GENET, 77(1-2), W2.
Flint, J., & Corley, R. (1996, September). Do animal models have a place in the genetic analysis of quantitative human behavioural traits?. J Mol Med (Berl), 74(9), 515-521.
Ning, Y., Roschke, A., Smith, A. C. M., Macha, M., Precht, K., Riethman, H., . . . Brown, W. R. A. (1996, September). A complete set of human telomeric probes and their clinical application. NAT GENET, 14(1), 86-89.
Flint, J., Rochette, J., Craddock, C. F., Dod, C., Vignes, B., Horsley, S. W., . . . Higgs, D. R. (1996, August). Chromosomal stabilisation by a subtelomeric rearrangement involving two closely related Alu elements.. Hum Mol Genet, 5(8), 1163-1169.
Flint, J., & Wilkie, A. O. (1996, July). The genetics of mental retardation.. Br Med Bull, 52(3), 453-464.
Flint, J. (1996, May). Annotation: behavioural phenotypes: a window onto the biology of behaviour.. J Child Psychol Psychiatry, 37(4), 355-367.
Raynham, H., Gibbons, R., Flint, J., & Higgs, D. (1996, March). The genetic basis for mental retardation.. QJM, 89(3), 169-175.
FLINT, J., CORLEY, R., DEFRIES, J. C., FULKER, D. W., GRAY, J. A., MILLER, S., . . . COLLINS, A. C. (1995, September 8). A SIMPLE GENETIC-BASIS FOR A COMPLEX PSYCHOLOGICAL TRAIT IN LABORATORY MICE. SCIENCE, 269(5229), 1432-1435.
CORLEY, R. P., CHERNY, S. S., FULKER, D. W., DEFRIES, J. C., GOODMAN, D. W., FLINT, J., . . . COLLINS, A. C. (1995, May). COMPARISON OF REGRESSION AND MAXIMUM-LIKELIHOOD APPROACHES TO QUANTITATIVE TRAIT LOCUS INTERVAL MAPPING IN F2 EXPERIMENTS INVOLVING SELECTED SAMPLES. BEHAV GENET, 25(3), 260.
Flint, J., Wilkie, A. O., Buckle, V. J., Winter, R. M., Holland, A. J., & McDermid, H. E. (1995, February). The detection of subtelomeric chromosomal rearrangements in idiopathic mental retardation.. Nat Genet, 9(2), 132-140. doi:10.1038/ng0295-132
WILSON, L. C., LUTTIKHUIS, M. E. M. O., FLINT, J., LEONARD, J. V., & TREMBATH, R. C. (1995, February). BRACHYDACTYLY AND MENTAL-RETARDATION - A NEW HAPLOINSUFFICIENCY SYNDROME. J MED GENET, 32(2), 144.
WILSON, L. C., LEVERTON, K., LUTTIKHUIS, M. E. M. O., OLEY, C. A., FLINT, J., WOLSTENHOLME, J., . . . TREMBATH, R. C. (1995, February). BRACHYDACTYLY AND MENTAL-RETARDATION - AN ALBRIGHT HEREDITARY OSTEODYSTROPHY-LIKE SYNDROME LOCALIZED TO 2Q37. AM J HUM GENET, 56(2), 400-407.
Flint, J., Craddock, C. F., Villegas, A., Bentley, D. P., Williams, H. J., Galanello, R., . . . Higgs, D. R. (1994, September). Healing of broken human chromosomes by the addition of telomeric repeats.. Am J Hum Genet, 55(3), 505-512.
MCDERMID, H. E., NESSLINGER, N., FLINT, J., EMANUEL, B. S., & BUDARF, M. L. (1994). MAPPING OF CHROMOSOME 22Q13.31 TO THE TELOMERE. CYTOGENET CELL GENET, 67(4), 289.
Harding, R. M., Boyce, A. J., Martinson, J. J., Flint, J., & Clegg, J. B. (1993, November). A computer simulation study of VNTR population genetics: constrained recombination rules out the infinite alleles model.. Genetics, 135(3), 911-922.
Flint, J., Harding, R. M., Boyce, A. J., & Clegg, J. B. (1993, March). The population genetics of the haemoglobinopathies.. Baillieres Clin Haematol, 6(1), 215-262.
Flint, J., Harding, R. M., Clegg, J. B., & Boyce, A. J. (1993, March). Why are some genetic diseases common? Distinguishing selection from other processes by molecular analysis of globin gene variants.. Hum Genet, 91(2), 91-117.
FLINT, J., RYDER, O. A., & CLEGG, J. B. (1990). COMPARISON OF THE ALPHA-GLOBIN GENE-CLUSTER STRUCTURE IN PERISSODACTYLA. J MOL EVOL, 30(1), 36-42.
Flint, J., Boyce, A. J., Martinson, J. J., & Clegg, J. B. (1989, October). Population bottlenecks in Polynesia revealed by minisatellites.. Hum Genet, 83(3), 257-263.
OSHAUGHNESSY, D., FLINT, J., THEIN, S. L., & MORTENSEN, N. (1988, December). EVIDENCE AGAINST THE ROLE OF CHROMOSOMES 17P AND 5Q IN EARLY COLORECTAL CARCINOGENESIS. BRIT J SURG, 75(12), 1247-1248.
Weatherall, D. J., Bell, J. I., Clegg, J. B., Flint, J., Higgs, D. R., Hill, A. V., . . . Thein, S. L. (1988, October 31). Genetic factors as determinants of infectious disease transmission in human communities.. Philos Trans R Soc Lond B Biol Sci, 321(1207), 327-348.
Flint, J., Taylor, A. M., & Clegg, J. B. (1988, February 5). Structure and evolution of the horse zeta globin locus.. J Mol Biol, 199(3), 427-437.
Bowling, A. T., Scott, A. M., Flint, J., & Clegg, J. B. (1988). Novel alpha haemoglobin haplotypes in horses.. Anim Genet, 19(2), 87-101.
THEIN, S. L., JEFFREYS, A. J., GOOI, H. C., COTTER, F., FLINT, J., OCONNOR, N. T. J., . . . WAINSCOAT, J. S. (1987, April). DETECTION OF SOMATIC CHANGES IN HUMAN CANCER DNA BY DNA FINGERPRINT ANALYSIS. BRIT J CANCER, 55(4), 353-356.
Hill, A. V., Flint, J., Weatherall, D. J., & Clegg, J. B. (1987). Alpha-thalassaemia and the malaria hypothesis.. Acta Haematol, 78(2-3), 173-179.
FLINT, J., HILL, A. V. S., BOWDEN, D. K., WEATHERALL, D. J., HIGGS, D. R., & CLEGG, J. B. (1986, December). THE ASSOCIATION OF ALPHA-THALASSEMIA AND MALARIA IN MELANESIA. BRIT J HAEMATOL, 64(4), 829.
FLINT, J., HILL, A. V. S., WEATHERALL, D. J., CLEGG, J. B., & HIGGS, D. R. (1986, August). ALPHA-GLOBIN GENOTYPES IN 2 NORTH EUROPEAN POPULATIONS. BRIT J HAEMATOL, 63(4), 796-797.
HIGGS, D. R., WAINSCOAT, J. S., FLINT, J., HILL, A. V. S., THEIN, S. L., NICHOLLS, R. D., . . . WEATHERALL, D. J. (1986, July). ANALYSIS OF THE HUMAN ALPHA-GLOBIN GENE-CLUSTER REVEALS A HIGHLY INFORMATIVE GENETIC-LOCUS. P NATL ACAD SCI USA, 83(14), 5165-5169.
FLINT, J., HILL, A. V. S., BOWDEN, D. K., OPPENHEIMER, S. J., SILL, P. R., SERJEANTSON, S. W., . . . CLEGG, J. B. (1986, June 19). HIGH-FREQUENCIES OF ALPHA-THALASSEMIA ARE THE RESULT OF NATURAL-SELECTION BY MALARIA. NATURE, 321(6072), 744-750.
THEIN, S. L., OSCIER, D. G., FLINT, J., & WAINSCOAT, J. S. (1986, May 1). HA-RAS HYPERVARIABLE ALLELES IN MYELODYSPLASIA. NATURE, 321(6065), 84-85.
HILL, A. V. S., BOWDEN, D. K., FLINT, J., WHITEHOUSE, D. B., HOPKINSON, D. A., OPPENHEIMER, S. J., . . . CLEGG, J. B. (1986, March). A POPULATION GENETIC SURVEY OF THE HAPTOGLOBIN POLYMORPHISM IN MELANESIANS BY DNA ANALYSIS. AM J HUM GENET, 38(3), 382-389.
WAINSCOAT, J. S., HILL, A. V. S., BOYCE, A. L., FLINT, J., HERNANDEZ, M., THEIN, S. L., . . . CLEGG, J. B. (1986, February 6). EVOLUTIONARY RELATIONSHIPS OF HUMAN-POPULATIONS FROM AN ANALYSIS OF NUCLEAR-DNA POLYMORPHISMS. NATURE, 319(6053), 491-493.