2013

First IVF baby born after sequencing screen

First IVF baby born after sequencing screen

Updated 17/07/2013

The first baby has been born in the US using a new technique developed with researchers at the Wellcome Trust Centre for Human Genetics, in which next-generation sequencing is used to screen IVF embryos for lethal aneuploidies (abnormal chromosome counts). This pioneering test was developed and validated with support from the NIHR Oxford Biomedical Research Centre (BRC) by BRC researchers based at the WTCHG, as part of an international collaboration led by Dr Dagan Wells of the Nuffield Department of Obstetrics and Gynaecology. The new technique is predicted to revolutionise the future of IVF testing.

New malaria animation

New malaria animation

Updated 08/07/2013

This animation about research into the malaria parasite and its control has just been launched on YouTube. The animation introduces malaria and goes on to illustrate how DNA sequencing technologies can be used to better track drug resistant malaria ...

Fast viral RNA sequencing for medical diagnosis

Fast viral RNA sequencing for medical diagnosis

Updated 08/07/2013

A team from the Wellcome Trust Centre for Human Genetics, working with consultant microbiologist Professor Derrick Crook in the John Radcliffe Hospital, has adapted RNA shotgun sequencing to the task of recovering and assembling the whole genomes of viruses in biological samples. They used the method to recover norovirus and hepatitis C from faecal and blood samples, a step towards using whole-genome sequencing for rapid diagnosis in the clinic. The work is part of the 'Modernising Medical Microbiology' initiative funded by the Wellcome Trust and the Medical Research Council, and is published online in Plos One.

Receptor clusters may hold clue to cancer therapy

Receptor clusters may hold clue to cancer therapy

Updated 02/07/2013

Researchers in Structural Biology (STRUBI) at the Wellcome Trust Centre for Human Genetics have demonstrated a new signalling mechanism that operates between cells, and shown how it might be manipulated as a therapy for cancer. Proteins on the ...

New genes, more complexity from in-depth study of rat genome

Updated 18/06/2013

Researchers at the WTCHG have carried out an extensive analysis of the genomes of laboratory rats, combining mapping and sequencing techniques to discover 35 genes that contribute to 31 conditions such as multiple sclerosis, anxiety and ...

New cancer gene testing programme launched

New cancer gene testing programme launched

Updated 23/05/2013

A collaboration between the WTCHG and the Institute of Cancer Research has won £2.7m from the Wellcome Trust for a research programme leading to a test for almost 100 genes that predispose people to cancer, using screening methodology developed by Illumina. WTCHG's contribution has been to develop the methods of analysis for the genetic data. 'A real strength of this programme is that the analysts are working directly with the people in the lab generating the data and the doctors that need to use it', says Professor Peter Donnelly, Director of WTCHG.

David Cameron visits WTCHG

David Cameron visits WTCHG

Updated 12/06/2013

Prime Minister David Cameron visited the Centre on Friday 3 May while he was in Oxford to attend the launch of the Li Ka Shing Centre for Health Information and Discovery. He met Centre director Peter Donnelly and a group of early career ...

Malaria markers for quick, accurate diagnosis

Malaria markers for quick, accurate diagnosis

Updated 23/05/2013

Climent Casals-Pascual and his colleagues at the WTCHG have identified parasite proteins that are accurate indicators of both the presence and severity of malaria. 'With these markers, more accurate diagnostic kits can be developed,' says Dr Casals-Pascual, 'so quick, correct diagnosis can lead to correct treatment.' These proteins are now available for development through Isis Innovation, the Technology Transfer Company of the University of Oxford.

Genetic fingerprinting can track resistance in malaria parasites

Genetic fingerprinting can track resistance in malaria parasites

Updated 29/04/2013

Dominic Kwiatkowski and his colleagues at the Wellcome Trust Centre for Human Genetics and the Sanger Institute have found distinct sub-populations of malaria parasites in Western Cambodia that are resistant to artemisinin, currently the most effective anti-malaria drug available worldwide. The 'fingerprinting' technique used by the group can provide a rapid and reliable method of tracking artimesinin resistance. The new study is published in the journal Nature Genetics.

Jeremy Farrar to head Wellcome Trust

Jeremy Farrar to head Wellcome Trust

Updated 24/04/2013

Jeremy Farrar, Professor of Tropical Medicine and Global Health at Oxford University and Director of the Oxford University Clinical Research Unit in Vietnam, has been appointed Director of the Wellcome Trust. He will take over his new post on 1 October 2013. Professor Farrar has worked closely with WTCHG researchers who are interested in the genetics and epidemiology of malaria and other tropical diseases.